?, Satan and The Lamb as Tainted Blue Baby, Drops 2 bombs at once (only 1 bomb is removed from your total), UNLOCK: Unlock this trinket by defeating Mother as Tainted Blue Baby. * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, If you touch an enemy in that time, Isaac will pick it up and slam it on the ground, killing it and sending a shockwave around the impact, In the brief period while holding the enemy you can move a target to decide where it lands, Actually does work on bosses! smile, lil' brimstone, Prevents Isaac from taking any damage, but instead summons a familiar heart that follows you around. While at full red health you also shoot a projectile across the room with each swing, dealing your current Damage + 2 (similar to the Master Sword in Zelda), UNLOCK: Unlock this item by defeating challenge #39 (Isaac's Awakening), While held, a red outline of a door will appear on certain walls. Spindown Dice is the only dice item that cannot be copied by the D Infinity. Holding this trinket increase that chance by +15%. Items that are better than the average and are good additions to have on most builds. * golden chest pool, gold chest pool, item room, treasure room, item room pool, green, ball, These only appear if not all runes have been unlocked yet. uses as his main mechanic, Killing or damaging enemies spawns various poops, which add to his collection. Please check out these videos here:https://www.youtube.com/playlist?list=PLateWiNrGEtqO2DY9I0wxVqRGrwrgJJWh-----. Aries, Cancer, Capricorn, Leo etc.). This includes damage you deal, and environmental damage they take e.g. E, space, or enter can be used to select an item. When used, this card drops all of your hearts (including non-red hearts), coins, keys and bombs on the floor, This effect is done in the most efficient way possible - e.g. changes: Brimstone to brimstone gfuel isaac's tears to isaac . +4 damage from Curved Horn instead of 2, -4 Tear Delay from Cancer instead of 2), Item Pool: Shop, Greed Mode Shop, Mom's Chest, Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. This allows you to stay alive as long as you don't get hit during this 10 second period, After this effect occurs, it cannot activate again until Isaac gains a half or full Soul Heart or a Black Heart. Tap the drop button to cycle between each one, Changes all card and rune drops into pills. The Knife Piece 1 is located in the Item Room in the mirrored area. ), Doesn't show the location of Secret or Super Secret rooms, Room icons will not show if a Curse of the Lost is in effect on the current floor, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, pink, red, Heals one red heart container when picked up, Item Pool: Boss Room, Challenge Room, Beggar, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, brown, bowl, grey, gray, poop, fly, Item Pool: Boss Room, Beggar, Challenge Room, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, dog, can, tin, brown, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, dog, brown, sack, bag, fly, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, carton, fly, flies, milk, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, green, bone, lump, yellow. ), and much much more! Can be used to store up to 8 consumables in, such as hearts, coins, keys, bombs, cards etc, When the bag has 8 items you can hold down the activate button for 2 seconds to craft yourself a brand new random item, Bag of Crafting's recipes are based on your current seed, but there are some fixed recipes that exist in every run, e.g. After killing a 15 enemies, Blood Puppy transforms into an aggressive version that will also attack Isaac by charging at him. e.g. Based on the Steam Workshop mod created by Scayze and Ashkait, *, eyes, eyeball, bloody, white, red, googly googley, bank shot, Upon entering a room, a skull appears over a random enemy's head, Killing the marked enemy will cause the skull to move to a different enemy, If all enemies in the room are cleared in the order they are marked, Isaac gains a random reward from one of the following: Soul heart, Key, Pill, Bomb, Nickel, +0.2 Speed, +0.5 Range, +0.5 Tears, +1 Flat damage or +1 luck, Killing enemies in the wrong order will end the streak and deny you any extra rewards, Added as part of the Afterbirth+ Booster Pack #4. How to see what items do in Binding of isaac. For example, an item which usually gives +1 Damage would instead give a small 'all stats up', Stats effected by this item are: Damage, Tears, Range, Speed, When taken with another item which gives an extreme value in a certain stat (e.g. treasure room, item room pool, yellow, golden, ring, circle, Item Pool: Item Room, Shop, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, item room, treasure room, item room pool, yellow, red, blue, medicine, jar, drug, moms bottle of pills, Tears now have a random chance to apply a poison effect, causing double your tear damage per tick to enemies over time, The chance to fire poison shots is affected by your luck stat and at +12 Luck it will activate every time, * item room, treasure room, item room pool, green, snot, booger, ball, slime, Isaac's tears now split into two upon contact with enemies or the environment, Tears that split off from the main tear do less damage (tear damage * 0.5), Tears can keep splitting if they still have range and damage above 1, UNLOCK: Unlock this item by collecting two of the following items: Bob's Rotten Head, Dead Cat, Cricket's Head, Tammy's Head, * item room, treasure room, item room pool, pink, slug, bug, face, When used, replaces all pedestal items in the current room with another random item. Items in general are classified into a number of distinct types and groups. This room will always drop a reward at the end, then allow you to exit back to the real floor, UNLOCK: Unlock this trinket by defeating The Beast as Tainted Cain, While held this trinket causes spikes to retract into the floor, Works for curse rooms - you no longer take damage entering or leaving, Allows you to open spiked chests without taking damage, Allows Planetariums to spawn in the Womb/Utero floors, Planetarium have a base 1% chance to appear, which increases by +20% whenever you skip an Item Room (Must not enter to count as skipped), After entering a Planetarium the chance goes back to 1%. sack, pouch, blue, purple, Tears gain a damage up and increase in size based on the distance they travel, The length of a normal room roughly gives +6 damage, but this can be higher with double rooms or Tiny Planet, This item synergises with beam items such as Brimstone and Tech, allowing them to do more damage the further away the enemy is, When used, removes one heart container and gives you 3 soul hearts, Item Pool: Devil Room, Curse Room, Red Chest, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, pink, purple, Spawns a familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one, The Leech deals 1.5 contact damage per tick, * item room, treasure room, item room pool, grey, gray, worm, A bag that follows Isaac and drops a random heart, coin, bomb or key every 5-6 rooms (alternating, 5 rooms then 6, then repeats), Can drop any kind of heart, coin, bomb or key, UNLOCK: Unlock this item by beating the Dark Room with Eden, Item Pool: Item Room, Beggar, Secret Room, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, secret room pool, item room, treasure room, item room pool, mysterious sack, multiple sacks, bag, pouch, purple, question mark, A large familiar black fly that bounces around the room, exploding on contact with enemies dealing 70 damage, Does not explode if it hits Isaac, however if it explodes on an enemy while Isaac is in range, he will take damage, Respawns after 10 seconds or by moving to another room, * item room, treasure room, item room pool, heart, smile, A green brain that launches in the direction you are firing your tears and will explode on contact with enemies, dealing damage and poisoning anything in the blast radius, Bob's Brain deals 100 damage and applies a poison damage over time effect, which deals double your tear damage per tick, Will hurt Isaac if he is in the blast radius. * shop room pool, shop item pool, the lost item pool, white, Causes Isaac's head to detach and orbit his body, blocking shots and dealing 7 contact damage per tick, BFFs will cause the Guillotine head to do double damage (14 damage per tick), Tears are still fired from Isaac's head but the hitbox remains around his body, UNLOCK: Unlock this item by beating the Isaac boss with Judas, * item room, treasure room, item room pool, chop, head, silver, metal, Gives Isaac an orbital ball of bandages that deals 7 contact damage per tick and blocks enemy shots, Collecting a second Ball of Bandages in the run turns the orbital into a pink head that shoots tears that deal 7 damage each and have a chance to charm enemies, Getting a third Ball of Bandages will transform the head into bandage girl which will chase enemies dealing 3.5 contact damage per tick while firing charm tears, A fourth Ball of Bandages will make the Bandage Girl bigger and stronger, making her deal 5.5 damage per tick instead, Any further Ball of Bandages will repeat the cycle, Increases the chance of champion enemies appearing by 15%, Doesn't affect the chance for champion bosses to spawn, * shop room pool, shop item pool, red, croissant, crescent, Bombs now become poop bombs, which deal 10 damage to all enemies in the room and daze them for a short period of time, Butt Bombs heal the poop bosses (Dingle, Dangle, Brownie) by 25% of their max HP, * boss rush pool, boss rush room, item room, treasure room, item room pool, poop, face, brown, If Isaac stands still and stops shooting for a second, he turns to stone, making him invincible until he moves/shoots again, Using bombs or your active item will remove the invicibility as well, This item is a reference to the Tanuki suit in Super Mario 3, * item room, treasure room, item room pool, raccoon, green, Spawns 2-5 friendly attack spiders every time you take damage, REPENTANCE - Buffed, used to spawn 1-2 spiders, * item room, treasure room, item room pool, the lost item pool, purple, blue, heart, cute spider baby, When Isaac dies, he has a 50% chance to resurrect with 1/2 a heart, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, Based on the Steam Workshop mod (originally called Hungry Tears) created by Echo, UNLOCK: Unlock this item by taking 10 Tears Up items or pills in the same run, Isaac's tears are replaced with piercing holy flashes of light, which travel across the room in a similar speed to regular tears, Trisagion tears deal roughly 33% of your usual tear damage, however due to the size of the holy flash it is likely to hit enemies multiple times, Trisagion tears cause no knockback on enemies and simply travel through them (piercing tears), Added as part of the Afterbirth+ Booster Pack #4. This effect also works on Delirium if it is currently transformed into The Haunt while below half health, UNLOCK: Unlock this item by defeating Greedier mode as Bethany, Identified all pills on pickup, and converts them to their worse counterparts (e.g. Stat Down pills do nothing, and items like Experimental Treatment increase stats but don't reduce any, This effect works on items that apply negative stat modifiers, such as Soy Milk, This effect works for anything that gives temporary buffs, like Devil/Strength cards, or kill bonuses like Bloody Lust, If you somehow lose Rock Bottom, your stats will go back to normal, UNLOCK: Unlock this item by defeating the Boss Rush as Jacob & Esau, Bombs now explode with a random effect (e.g. in shops or devil rooms), The only way to survive the falling sword is either through extra lives, by using items that would make you invincible, such as Gnawed Leaf or playing as The Lost. This chance doesnt change if you take further damage, You effectively have a 4.4% chance for every minute that passes after taking damage to die, Self-inflicted damage i.e. Donation machines become fixed if they were jammed before using the R Key, Isaac now has a chance to fire a fist instead of normal tears, which have a much higher knockback effect and confuse enemies for a few seconds, Enemies that are knocked back will take 10 damage and knock back any enemy they are knocked into, dealing damage to them as well, An active item that allows you to throw an eraser at any enemy, which will kill it and prevent it from appearing for the rest of the run, Enemies that are erased create a puff of smoke instead of spawning, Works on bosses, except it doesn't kill them it just deals 15 damage, Can only be used once per floor - batteries also cannot be used to recharge it to bypass this restriction, The first use will raise it above your head, then by pressing the fire button it will be thrown in that direction, Recharge time: 1 room (Can only be used once per floor), When used, this item will give you +1 Rotten Heart, Rotten Hearts act as red hearts and each one you currently have spawns 2 blue flies upon successfully clearing a room, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Maggy, Enemies now create a soul upon death, which is automatically sucked into the Urn giving it +1 charge. At +0 Luck theres a ~2.5% chance for this effect to activate, The size of the rift scales with your tear damage, In Antibirth this item was called Oculus Rift, A familiar boil that randomly fires bursts of tears, similar to the Boil enemy, A familiar baby that fires tears which have a chance to freeze or petrify enemies, When used, rerolls all items in the room into another random item from the current room's item pool, however the item also has a 30% chance to disappear, The chance associated with this item does NOT scale with your Luck stat - it's always 30%, In the game files this item is called 'Florians Dice', which is a reference to the Eternal update for the original Binding of Isaac game, which changed the D6 to act as this item does. This page documents some of the more noteworthy item synergies available. However, the item ID's go from 1 (The Sad Onion) to 552 (Mom's Shovel), because five ID's are unused. I don't intend in publishing it anywhere when I finish it, but I do want to know opinions . The main purpose of the Cracked Key is to unlock Tainted character in the Home floor without needing to find the Red Key. UNLOCK: Unlock this card by opening Mom's Box on the Home floor. * bogey, boger, green, drop, drip, boogey, Adds a chance to shoot a concussive tear, which will cause enemies to walk around dazed in confusion, The daze effect is effectively permanent for normal enemies, and has a much longer duration for bosses compared to other status effects, The visual effect of a Glaucoma tear is hard to notice, however it is slightly lighter than normal tears and is not a perfect circle shape, This item gives you a chance that instead of firing tears you will fire an egg sack, which slows enemies on hit and drops a pool of white slowing creep below them, If a parasitoid shot successfully hits an enemy, a blue friendly fly or spider is spawned. The laser hits up to 13 times if an enemy stays inside it for the duration, Has a chance to drop from the Envy and Super Envy miniboss fights, Item Pool: Item Room, Envy Miniboss, Super Envy Miniboss, * item room, treasure room, item room pool, red, lips, white, eyes, UNLOCK: Unlock this item by beating the Basement 40 times and defeating the Steven boss, *, black, white, face, eyes, mouth, golden chest pool, +10% chance of a devil/angel room opening while held, A second Pentagram will give an extra +5% chance, Counts as 1 of 3 evil items needed towards the Leviathan transformation, Item Pool: Boss Room, Curse Room, Devil Room, Demon Beggar, Crane Game, * curse room pool, devil pool, devil room pool, devil deal, boss room pool, boss room item, Kreuzfahrer Jan 15, 2017 @ 2:03am. Spawns coins as The Keeper, I can see forever - Opens secret room and super secret room entrances on the current floor, I found pills - Changes the appearance of Isaac's face for the current room (Cosmetic change only), Lemon Party - Spawns a large yellow pool on the floor around you, damaging enemies which walk in it, Paralysis - Prevents you from moving for a short while, Pheromones - Applies the charm effect to all enemies in the room for a short while, Puberty - Causes Isaac to grow hair for the rest of the run. Isaac.Spawn (EntityType.ENTITY_PICKUP, PickupVariant.PICKUP_COLLECTIBLE, <item name>, <position vector>, <speed vector>, <entity spawner, you can just leave this as nil>) Isaac . Items for 15c, hearts for 3c, sacks for 7c, UNLOCK: Unlock this card by defeating challenge #44 (Red Redemption), Activates a random effect from a Dice room, See the dice icon above for each possible effect, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Cain, All enemies in the current room are slowed and take double damage, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Samson, You turn into the Keeper, gaining triple shot, -0.1 Speed Down for 30 seconds, Enemies drop random coins while this effect is active, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Keeper, Activates the Book of the Dead effect, spawning a bone orbital or charmed Bony for each enemy killed in the current room, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Forgotten, When used, this card activates 5 random pill effects one after the other, UNLOCK: Unlock this card by defeating challenge #45 (DELETE THIS), Activates The Bible effect (granting flight) and gives a Seraphim familiar for 30 seconds, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Azazel, Spawns 6 clusters of rocks and objects that normally appear on this floor, Rocks have a pretty good chance to become tinted rocks, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Apollyon, Removes your oldest item and spawns 2 pedestal items from the current room's pool, Can remove either passive or active items, Doesn't remove your character's starting items, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Isaac, Teleports you to the ultra secret room on the floor, The ultra secret room is a red room containing an item from the angel room item pool. Each tick of poison damage is equal to your normal tear damage, Some random tears will gain the Rubber Cement effect and become bouncy, Grants +0.25 Speed, +0.75 Range, +0.1 Shot Speed, +0.2 Tears, +0.5 Damage and +1 Luck when Isaac's active item is fully charged, Infinite use items such as Potato Peeler count as charged and provide the bonus from this trinket, Grants +0.5 Speed, +1.5 Range, +0.3 Shot Speed, +0.4 Tears, +1.5 Damage when Isaac's active item is completely uncharged, One-time use items such as Mama Mega count as uncharged and provide the bonus from this trinket, Gives you another secret room on each new floor while held, Does not spawn more than one super secret room, only the normal secret room, *, purple, torn, ripped, paper, page, poster, When you have the same amount of coins, bombs and keys, half consumables turn into their doubled version, This effect works for any number of consumables, including 0 and 99, as long as the count for coins/keys/bombs is equal, Every time you take damage you have a very small chance to spawn a random pedestal item, When the effect triggers, the trinket is destroyed, Every time you take damage you have a very small chance to spawn the Lunch item, which gives +1 HP up, When the effect triggers, this trinket is destroyed, Increases the radius of any creep you produce, While held, any damage taken remove red hearts first, before soul hearts, black hearts and rotten heart damage, While at 1/2 of a red heart, it will begin to remove your other hearts again, UNLOCK: Unlock this item by beating Greedier mode with Eve, The Walnut has a chance to break when taking damage from an explosion. - Spawns the last pill you used. UNLOCK: Unlock this item by beating the Boss Rush with Azazel, * devil pool, devil room pool, devil deal, grey, gray, bloody, Spawns a trapdoor at Isaac's feet which allows him to travel to the next floor, Digging in certain spots with objects or markings on the floor will guarantee a crawlspace once per floor, In Sheol, Cathedral, Chest and Dark Room this item either opens a Crawl Space, or does nothing, Cannot spawn a trapdoor directly infront of a secret room entrance, Can destroy rocks if used when Isaac is flying over a rock, * secret room pool, devil pool, devil room pool, devil deal, silver, grey, gray, dig, spade, shovel, Counts as 1 of 3 astrology items needed in the same run to unlock Planetariums, * shop room pool, shop item pool, item room, treasure room, item room pool, brown, pink, When used, spawns a Monstro which will jump on a random enemy in the room, dealing 120 damage and destroying nearby obstacles, UNLOCK: Unlock this item by beating the Basement II for the first time, * item room, treasure room, item room pool, white, grey, gray, bloody, monstros tooth, monstro tooth, Everytime you fire a tear, there is a chance that you will also fire three more tears in all cardinal directions, The chance to fire 4-way tears is affected by your luck stat and at +15 Luck it will activate every time, At +0 luck the effect has a 30% chance to activate, UNLOCK: Unlock this item by beating Lokii for the first time, * item room, treasure room, item room pool, grey, gray, devil, lokis horns loki horns, A familiar that follows Isaac and charges forwards, dealing 3.5 damage per tick to any enemies it comes into contact with, REPENTANCE - The damage tick rate on Little Chubby has been increased, UNLOCK: Unlock this item by beating the Caves II for the first time, * item room, treasure room, item room pool, yellow, smile, face, bug, Tears now have a chance of slowing enemies and their projectiles for 2.5 seconds, The chance to slow enemies is affected by your luck stat and at +15 Luck it will activate every time, * item room, treasure room, item room pool, black, grey, gray, red, bug, Has a chance to drop when exploding a tinted rock, UNLOCK: Unlock this item by destroying 100 tinted rocks, * tinted rock, marked rock, grey, gray, lump, white, Reveals adjacent rooms up to 2 rooms away, this includes revealing if you're next to a Secret Room or Super Secret Rooms, Gives Isaac a slight glow when Curse of Darkness is active, Blocks damage from projectiles falling from above, * item room, treasure room, item room pool, spelunky, miner, mining, helpmet, light, purple, olmec yama Bombs, keys, cards, runes and batteries have a 20% chance, Can lead to game-breaking combinations with the D20 due to the amount of consumables and batteries spawned by the item sacks, REPENTANCE - Added to the Secret Room pool. After reaching level 4 (and at a much lower chance before level 4), Bumbo will also continue to collect coins and drop random pickups, similar to the Bum Friend item, but can also drop pedestal items very rarely. * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Thanks in advance. Everything is sold for its shop price, e.g. To help with range, the orbit is now also offset based on the current direction Isaac is shooting, * item room, treasure room, item room pool, grey, gray, asteroid, silver, ball, Creates a friendly blue spider when you kill an enemy, Spiders are spawned at the location where the enemy died, * item room, treasure room, item room pool, pink, smile, E. Coli turns normal enemies into poop if they touch you, Enemies can turn into poop even if they do not do contact damage, allowing you to apply the effect without taking damage, Can be combined with Midas Touch to turn enemies into Golden Poop, This does not work on mini-bosses and bosses. Following the path takes you to an abandoned mineshaft, which leads you to a pedestal with the Knife Piece. Based on the Steam Workshop mod created by Ink Tears, UNLOCK: Unlock this item by having two items or effects that grant homing shots at once (e.g. I've redone some of the TBOI's items, here's a showcase of just 4 of ones I've changed (right now I've modified a total of 19 items), which I personally think needed a change. ?, Paralysis, Retro Vision, I'm Excited, While held, gives you an orbital that blocks enemy shots and deals contact damage equal to 3.5 per tick, While the active key is held down, Isaac gains +0.5 Speed and all of your orbitals spin faster and deal more damage, Orbital damage is equal to 1.5 x OrbitalDamage + 6 while this effect is active, On death enemies now fire tears in random directions, which can damage other enemies, The amount of tears created by this effect depends on the total health of the enemy killed. - Every HP upgrade is now worth 2 soul hearts. Unlocked from Challenge #25 - Have a Heart, Feels like I'm walking on sunshine! white, grey, gray, A familiar that follows isaac around dropping white creep which slows down enemies that walk over it, Spawns 1-2 familiar blue spiders after every room, * item room, treasure room, item room pool, white, ball, dripping, A familiar that is controlled via the arrow keys and will automatically fire a laser if anything is in its line of sight, Robo-Baby 2.0's lasers deal 3.5 damage per hit, UNLOCK: Unlock this item by beating Challenge #16 (Computer Savvy), * robo baby 2.0, item room, treasure room, item room pool, red, eyes, grey, gray, robot, A familiar which follows Isaac and spawns a blue flies as you're firing tears, Rotten Baby can only create one fly at a time, meaning if he has created a fly he cannot make another until it is used, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, dead, baby, The Binding of Isaac: Rebirth Steam charts, data, update . Toxic Dips release a poison cloud when they move/die. * arcade, skull game, black, heart, pink, love, Gives Isaac 2 orbital flies which block enemy shots, Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies, * item room, treasure room, item room pool, key master pool, key beggar pool, key judgement pool, two, flies, black, When revived, the green mushroom that follows Isaac will disappear and he will respawn with the same amount of red heart containers at full health, Resurrection takes place before all other items which give you an extra life, * secret room pool, mario, green mushroom, extra life, spots, spotted, x1.5 times Damage Multiplier (Does not stack with the multipliers from Cricket's Head / Blood of The Martyr + Book of Belial), Increases the size of your player sprite, but doesn't increase the hitbox, Counts as 1 of 3 mushroom items needed towards the Fun Guy transformation, Counts as 1 of 3 size-increasing items needed towards the Stompy transformation, * boss room pool, boss room item, item room, treasure room, item room pool, red, spots, spotted, amanita muscaria, Enemies touching you take 12 damage, then a poison effect is applied for 6-7 ticks, dealing damage equal to the amount of red hearts you have (up to 30.8 at 12 full red hearts), Has a chance to drop from the Lust miniboss fight, Counts as 1 of 3 syringe items needed towards the Spun transformation. syringe, needle, injection, purple, grey, gray, Causes Isaac to shrink in size (including hitbox slightly), Can be dropped when exploding mushrooms in the environment that are usually found in the Caves/Catacombs and in secret rooms, * item room, treasure room, item room pool, mushroom, blue, spotted, Adds several instances of The Bible item into all item pools. This is shown by the Azazel skin spreading on Isaac's face, After 4 rooms, Isaac's face will flash red. The shield you gain recharges from leaving and entering rooms. Esc, backspace, or Q can be used to go back. After which, the only way to access an Angel Room is via the Sacrifice Room, * curse room pool, red chest pool, red chest item pool, golden chest pool, gold chest pool, devil pool, devil room pool, devil deal, brown, horns, When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect, * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool, devil pool,
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